Particle Therapy Co-Operative Group

An organisation for those interested in proton, light ion and heavy charged particle radiotherapy

Lymphoma Subcommittee

Co-Chairs:

This email address is being protected from spambots. You need JavaScript enabled to view it., Katerina Dedeckova, TBD

Charges: 

1) Understand the problems with photon radiation in management with lymphoma 

2) Demonstrate the potential benefit of using proton therapy dosimetry to improve upon the limitations of photon radiation listed in Charge 1) 

3) Review the current clinical data for using proton therapy in lymphoma and evidence for similarity in disease control

4) Understand which patients are currently receiving proton therapy for lymphoma

5) Share experience regarding how patients are being treated using proton therapy, including treatment planning challenges and developing
   best practices.

6) Provide opportunity for collaborative studies among centers evaluating proton therapy in larger combined cohorts

   a.  Hodgkin lymphoma

   b.  Non-Hodgkin lymphoma

   c.  Relapsed/Refractory lymphoma

7) Develop Prospective research: We would like to develop a lymphoma registry combining both proton and photon patients to collect both dosimetric
   data and clinical outcomes, in order to identify benefits from proton therapy long term. This registry could be developed in collaboration with ILROG

Bibliography:

PTCOG Lymphoma Subcommittee Work:

Evidence-based Review on the Use of Proton Therapy in Lymphoma From the Particle Therapy Cooperative Group (PTCOG) Lymphoma Subcommittee.
Tseng YD, Cutter DJ, Plastaras JP, Parikh RR, Cahlon O, Chuong MD, Dedeckova K, Khan MK, Lin SY, McGee LA, Shen EY, Terezakis SA, Badiyan SN, Kirova YM13, Hoppe RT, Mendenhall NP, Pankuch M, Flampouri S, Ricardi U, Hoppe BS. 
Int J Radiat Oncol Biol Phys. 2017 Sep 21. Pii: S0360-3016(17)30901 PMID: 28943076

Consolidative Proton Therapy after chemotherapy for patients with Hodgkin lymphoma.
Hoppe BS, Hill-Kayser CE, Tseng YD, Flampouri S, Elmongy HM, Cahlon O, Mendenhall NP, Maity A, McGee LA, Plastaras JP. 
Ann Oncology. 2017 Sep 1;28(9):2179-2184. PMID:28911093


PBS in Lymphoma:

Proton pencil beam scanning for mediastinal lymphoma: treatment planning and robustness assessment.
Zeng C, Plastaras JP, James P, Tochner ZA, Hill-Kayser CE, Hahn SM, Both S.
Acta Oncol. 2016 Sep-Oct;55(9-10):1132-1138 PMID27332881


Proton therapy and Breath Hold in Lymphoma:

Comparing Breath Hold and Free Breathing during Intensity-Modulated Radiation Therapy and Proton Therapy in Patients with Mediastinal Hodgkin Lymphoma.
Hoppe BS, Mendenhall NP, Louis D, Li Z, Flampouri S. 
Mar 2017, Vol. 3, No. 4 (Spring 2017) pp. 492-496

Life years lost attributable to late effects after radiotherapy for early stage Hodgkin lymphoma: The impact of proton therapy and/or deep inspiration breath hold.
Rechner LA, Maraldo MV, Vogelius IR, Zhu XR, Dabaja BS, Brodin NP, Petersen PM, Specht L, Aznar MC.
Radiother Oncol. 2017 Aug 21. pii: S0167-8140(17)32509-4. doi: 10.1016/j.radonc.2017.07.033. [Epub ahead of print] PMID: 28838605


Proton therapy in Non-Hodgkin lymphoma:

Proton therapy in the management of non-Hodgkin lymphoma.
Sachsman S, Flampouri S, Li Z, Lynch J, Mendenhall NP, Hoppe BS 
Leuk Lymphoma. 2015;56(9):2608-12 PMID 25669925


Clinical Trial Results:

Involved-node proton therapy in combined modality therapy in Hodgkin Lymphoma: results of a phase II study.
Hoppe BS, Flampouri S, Zaiden R, Slayton W, Sandler E, Ozdemir S, Dang NH, Lynch JW, Li Z, Morris CG, Mendenhall NP.
Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):1053-9. PMID: 24928256


Other:

Estimated risk of cardiovascular disease and secondary cancers with modern highly conformal radiotherapy for early-stage mediastinal Hodgkin lymphoma.
Maraldo MV, Brodin NP, Aznar MC, Vogelius IR, Munck af Rosenschöld P, Petersen PM, Specht L. 
Ann Oncol. 2013 Aug;24(8):2113-8. PMID: 23619032